I haven't tried this but will give it a whirl over the weekend.

I've got Newsgator delivering articles directly into my default folder, which is an exchange store (EX5.5), but I also have Exchange caching turned on, meaning that if I pull my network connection or the exchange server is unavailable my mail is still available to me.

How will Newsgator react in this situation.  If the exchange server is not available but outlook and Newsgator are open.  Newsgator goes out, gets the articles and tries to put them into the appropriate folders.  Is this going to work or die horribly?

Thanks

It should work as you expect...